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  1. N-Acetyl-S- (dichlorophenyl) cysteines as suitable biomarkers for the monitoring of occupational exposure to 1,2-dichlorobenzene.

    Article, Communication - En anglais

    European Meeting on Mass Spectrometry in Occupational Health. Erlangen (DEU), 1995/06/21.

    A method has been developed for the simultaneous analysis of the isomeric N-acetyl-S- (dichlorophenyl) cysteines (also known as dichlorophenylmercapturic acids, DCPMAs) in urine.

    This procedure allows the determination of 2,3-and 3,4-DCPMAs at the concentrations expected in the urine samples of employees occupationally exposed to 1,2-dichlorobenzene (1,2-DCB).

    The results of a 1,2-DCB exposure study under standardized conditions show a first-order kinetic for the excretion of DCPMAs, as well as acceptable linear correlations between the urinary concentrations of DCPMAs and the amount of inhaled 1,2-DCB.

    It therefore seems it would be possible to derive a biological tolerance value for 1,2-DCB based on isomeric DCPMAs as analytical parameters.

    Mots-clés Pascal : Benzène dérivé, Solvant organique, Exposition professionnelle, Médecine travail, Homme, Surveillance biologique, Marqueur biologique, Urine, Liquide biologique, Benzène(1,2-dichloro)

    Mots-clés Pascal anglais : Benzene derivatives, Organic solvent, Occupational exposure, Occupational medicine, Human, Biological monitoring, Biological marker, Urine, Biological fluid

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0250726

    Code Inist : 002B03L06. Création : 11/06/1997.