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  1. Leptospirosis : a problem for transfusion medicine ?

    Article - En anglais

    Copyright (c) 1996 Elsevier Science B.V. All rights reserved.

    Leptospirosis is underdiagnosed owing to its non-specific presentation, especially in the early stages of the infection.

    In the present research, sera from 2368 healthy blood donors of a local blood bank were screened for the presence of leptospiral antibodies using IgM-Pk-ELISA, followed by the microscopic and macroscopic agglutination tests.

    Serum samples showing two positive and/or borderline results in these assays were confirmed by immunoblotting.

    The IgM-antibody profile was defined according to the following criteria : sera reactive to a diffuse band of molecular weight 14.8-22 kDa were considered leptospirosis positive, sera exhibiting no reactivity to this band were considered negative.

    Our results showed a prevalence of 1.01% positivity.

    There is evidence that transmission of Leptospira interrogans by blood transfusion is possible, but, to date there has been no documentation of transfusion-transmitted leptospirosis.

    Thus, according to the currently available information, there is no need for new bloodbanking procedures to identify possible carriers of L. interrogans. 1997 Elsevier Science B.V.

    Mots-clés Pascal : Leptospira interrogans, Leptospiraceae, Spirochaetales, Bactérie, Leptospirose, Spirochétose, Bactériose, Infection, Détection, Anticorps, Sérum, Homme, Donneur sang, Survie, Sang total

    Mots-clés Pascal anglais : Leptospira interrogans, Leptospiraceae, Spirochaetales, Bacteria, Leptospirosis, Spirachaetosis, Bacteriosis, Infection, Detection, Antibody, Serum, Human, Blood donor, Survival, Whole blood

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0249508

    Code Inist : 002B05B02P. Création : 11/06/1997.