Objectives-To obtain summary measures of the relation between cumulative exposure to asbestos and relative risk of lung cancer from published studies of exposed cohorts, and to explore the sources of heterogeneity in the dose-response coefficient with data available in these publications.
Methods-15 cohorts in which the dose-response relation between cumulative exposure to asbestos and relative risk of lung cancer has been reported were identified.
Linear dose-response models were applied, with intercepts either specific to the cohort or constrained by a random effects model ; and with slopes specific to the cohort, constrained to be identical between cohorts (fixed effect), or constrained by a random effects model.
Maximum likelihood techniques were used for the fitting procedures and to investigate sources of heterogeneity in the cohort specific dose-response relations.
Estimates of the study specific dose-response coefficient (k1. i) ranged from zero to 42 x 10 3 ml/fibre-year (ml/f-y).
Under the fixed effect model, a maximum likelihood estimate of the summary measure of the coefficient (K1) equal to 0.42 x 103 (95% confidence interval (95% CI) 0.22 to 0.69 x 10-3) ml/f-y was obtained.
Under the random effects model, implemented because there was substantial heterogeneity in the estimates of k1. i and the zero dose intercepts (Ai), a maximum likelihood estimate of ki equal to 2.6 x 103 (95% CI 0.65 to 7. (...)
Mots-clés Pascal : Carcinogène, Amiante, Fibre minérale, Tumeur maligne, Bronchopulmonaire, Exposition professionnelle, Homme, Médecine travail, Chronique, Métaanalyse, Dose cumulée, Etude cohorte, Article synthèse, Revue bibliographique, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie
Mots-clés Pascal anglais : Carcinogen, Asbestos, Mineral fiber, Malignant tumor, Bronchopulmonary, Occupational exposure, Human, Occupational medicine, Chronic, Metaanalysis, Cumulated dose, Cohort study, Review, Bibliographic review, Respiratory disease, Lung disease, Bronchus disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0246826
Code Inist : 002B11A. Création : 11/06/1997.