Objectives-Previous research suggests that binding of lead by delta-aminolevulinic acid dehydratase (ALAD) may vary by ALAD genotype.
This hypothesis was tested by examining whether ALAD genotype modifies urinary lead excretion (DMSA chelatable lead) after oral administration of dimercaptosuccinic acid (DMSA).
Methods-57 South Korean lead battery manufacturing workers were given 5 mglkg oral DMSA and urine was collected for four hours.
Male workers were randomly selected from two ALAD genotype strata (ALAD1-1, ALAD1-2) from among all current workers in the two plants (n=290).
Subjects with ALAD1-1 (n=38) were frequency matched with subjects with ALAD1-2 (n=19) on duration of employment in the lead industry.
Blood lead, zinc protoporphyrin, and plasma aminolevulinic acid concentrations, as well as ALAD genotype, duration of exposure, current tobacco use, and weight were examined as predictors or effect modifiers of levels of DMSA chelatable lead.
Blood lead concentrations ranged from 11 to 53 mug/dl, with a mean (SD) of 25.4 (10.2) mug/dl.
After 5 mg/kg DMSA orally, the workers excreted a mean (SD) 85.4 (45.0) mug lead during a four hour urine collection (range 16.5-184.1 mug).
After controlling for blood lead concentrations, duration of exposure, current tobacco use, and body weight, subjects with ALAD1-2 excreted, on average, 24 mug less lead during the four hour urine collection than did subjects with ALAD1-1 (P=0.05). (...)
Mots-clés Pascal : Plomb, Homme, Métal lourd, Porphobilinogen synthase, Hydro-lyases, Carbon-oxygen lyases, Lyases, Enzyme, Génotype, Toxicocinétique, Pharmacocinétique, Cinétique, Métabolisme, Fixation biologique, Comparaison interindividuelle, Toxicogénétique, Génétique, Excrétion, Chélateur, Exposition professionnelle, Médecine travail, Corée du Sud, Corée, Asie, Succimer, Epidémiologie, DMSA
Mots-clés Pascal anglais : Lead, Human, Heavy metal, Porphobilinogen synthase, Hydro-lyases, Carbon-oxygen lyases, Lyases, Enzyme, Genotype, Toxicokinetics, Pharmacokinetics, Kinetics, Metabolism, Biological fixation, Interindividual comparison, Toxicogenetics, Genetics, Excretion, Chelating agent, Occupational exposure, Occupational medicine, South Korea, Korea, Asia, Succimer, Epidemiology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0246824
Code Inist : 002B03L05. Création : 11/06/1997.