Congenital malformations and maternal occupation : a registry based case-control study.
Objectives-To investigate the relations between congenital malformations and maternal occupation during pregnancy with a registry based case-control study.
Methods-Analysis was performed on data derived from the Florence Eurocat registry surveillance programme.
The study included cases with isolated conditions, including chromosomal anomalies (n=1351), cases with multiple anomalies registered during the 1980-91 period (n=440), and babies with no congenital malformations recognised at birth who were born from 1982 to 1989 and selected as controls (n=3223). 11 categories were defined, 10 including cases with isolated malformations and one for cases with multiple congenital anomalies.
Four categories of maternal occupation were selected for the study.
Odds ratio (OR) values were adjusted for maternal origin, maternal and paternal education, number of previous live births, illness during pregnancy, and maternal age when the group of chromosomal anomalies was analysed.
A notable and significant association between oral clefts and mothers involved in leather and shoe manufacturing was found (adjusted OR 3.9 ; 99% confidence interval (99% CI) 1.5 to 9.8) and the risk consistently increased when considering cases with isolated cleft palate separately (OR 5.4 ; 95% CI 1.8 to 13.4).
Moreover, a significant risk was identified for the association between multiple anomalies and textile dye workers (adjusted OR 1.9 ; 99% CI 1.0 to 3.8). (...)
Mots-clés Pascal : Malformation, Gestation, Tératogène, Exposition professionnelle, Médecine travail, Homme, Traitement mère, Epidémiologie, Italie, Europe, Registre, Etude cas témoin, Surveillance, Prévention
Mots-clés Pascal anglais : Malformation, Pregnancy, Teratogen, Occupational exposure, Occupational medicine, Human, Maternal treatment, Epidemiology, Italy, Europe, Register, Case control study, Surveillance, Prevention
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0246821
Code Inist : 002A30E. Création : 11/06/1997.