The purpose of this study was to use the breath ethane test to determine if either maternal cigarette smoking, formula, and/or deficiency of the antioxidant nutrients vitamins A and E was associated with oxidant stress in newborn infants.
I I) our observation that cigarette smoking was a source of oxidant stress in pregnant women, suggesting that it could be a source of oxidant stress for infants exposed in utero : (2) formula was predicted to be prooxidant compared to colostrum, which contains several compounds with antioxidant activity in vitro : and (3) deficiencies of vitamins A and E have been shown to promote oxidant stress in experimental animals.
Breath ethane, a volatile alkane produced by peroxide of n-3 fatty acids, was utilized as an index of oxidant stress status.
Forty-five healthy full-term infants of the women mentioned above were studied at 18-24 h of age, after four to six feedings of breast milk (colostrum) or casein-based infant formula.
Relationships between infant breath ethane, maternal smoking, mode of infant nutrition, and serum concentrations of the antioxidant vitamins A and E of infants were examined.
The breath ethane of the entire group of infants whose mothers smoked (n=19) was increased compared to values of infants whose mothers did not smoke (n=26) : 97 ± 16 versus 43 ± 9 pmol/kg/min, p<0.03. (...)
Mots-clés Pascal : Tabagisme, Relation mère foetus, Facteur risque, Allaitement, Colostrum, Antioxygène, Cigarette, Oxydant, Stress, Etude comparative, Ethane, Evaluation, Nouveau né, Homme, Appareil génital femelle pathologie, Glande mammaire pathologie
Mots-clés Pascal anglais : Tobacco smoking, Fetomaternal relation, Risk factor, Breast feeding, Colostrum, Antioxygen, Cigarette, Oxidant, Stress, Comparative study, Ethane, Evaluation, Newborn, Human, Female genital diseases, Mammary gland diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0246314
Code Inist : 002B20G01. Création : 11/06/1997.