Prooxidant effects of maternal smoking and formula in newborn infants.
The purpose of this study was to use the breath ethane test to determine if either maternal cigarette smoking, formula, and/or deficiency of the antioxidant nutrients vitamins A and E was associated with oxidant stress in newborn infants.
The rationale for this study was
I I) our observation that cigarette smoking was a source of oxidant stress in pregnant women, suggesting that it could be a source of oxidant stress for infants exposed in utero : (2) formula was predicted to be prooxidant compared to colostrum, which contains several compounds with antioxidant activity in vitro : and (3) deficiencies of vitamins A and E have been shown to promote oxidant stress in experimental animals.
Breath ethane, a volatile alkane produced by peroxide of n-3 fatty acids, was utilized as an index of oxidant stress status.
Forty-five healthy full-term infants of the women mentioned above were studied at 18-24 h of age, after four to six feedings of breast milk (colostrum) or casein-based infant formula.
Relationships between infant breath ethane, maternal smoking, mode of infant nutrition, and serum concentrations of the antioxidant vitamins A and E of infants were examined.
The breath ethane of the entire group of infants whose mothers smoked (n=19) was increased compared to values of infants whose mothers did not smoke (n=26) : 97 ± 16 versus 43 ± 9 pmol/kg/min, p<0.03. (...)
Mots-clés Pascal : Tabagisme, Relation mère foetus, Facteur risque, Allaitement, Colostrum, Antioxygène, Cigarette, Oxydant, Stress, Etude comparative, Ethane, Evaluation, Nouveau né, Homme, Appareil génital femelle pathologie, Glande mammaire pathologie
Mots-clés Pascal anglais : Tobacco smoking, Fetomaternal relation, Risk factor, Breast feeding, Colostrum, Antioxygen, Cigarette, Oxidant, Stress, Comparative study, Ethane, Evaluation, Newborn, Human, Female genital diseases, Mammary gland diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0246314
Code Inist : 002B20G01. Création : 11/06/1997.