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  1. Optimal vaccination strategies for a community of households.

    Article - En anglais

    The effectiveness of a vaccination program depends on how the vaccinations are spread over the households of the community.

    Here we formulate the optimal allocation of vaccinations as a linear programming problem, when the objective is to prevent epidemics with the minimum vaccination coverage.

    A vaccine efficacy of less than 100%, as is usual in practice, is allowed for.

    Optimal vaccine allocations attempt to leave the same number of susceptibles in every household if the disease has a very high transmission rate within households.

    This means that proportionately more individuals need to be vaccinated in larger households if the vaccine efficacy is<100%. The linear programming formulation can accommodate heterogeneity among individuals of the proportionate mixing form and can also minimize the initial reproduction number for a given achievable vaccination coverage.

    Mots-clés Pascal : Efficacité, Vaccination, Stratégie optimale, Prévention, Epidémie, Contamination, Immunisation, Approche probabiliste, Etude théorique

    Mots-clés Pascal anglais : Efficiency, Vaccination, Optimal strategy, Prevention, Epidemic, Contamination, Immunization, Probabilistic approach, Theoretical study

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0245820

    Code Inist : 002B30A03A. Création : 11/06/1997.