Common polymorphisms in the vitamin D receptor (VDR) gene have been shown to correlate with bone mineral density (BMD).
However, attempts to replicate the original findings in other populations have yielded variable results.
These disparities may reflect ethnic or environmental differences in the expression of the VDR effect upon BMD.
We examined a relatively ethnically homogeneous group of 103 healthy postmenopausal Caucasian women of Mexican descent living in Northern California.
We determined the VDR genotype and measured the BMD at the lumbar spine and femoral neck by dual-energy X-ray absorptiometry, as well as several biochemical indices of mineral metabolism.
The prevalence of the BB genotype, associated in previous studies with the lowest BMD, was 8% and highly linked to the tt genotype.
Absolute and age-adjusted BMD at both hip and spine showed a trend toward lower BMD in the BB, AA, and tt genotypes, but this trend did not achieve statistical significance.
There were no consistent intergroup differences in change in BMD over 2 years of follow-up, nor in mean serum concentrations of 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, osteocalcin, or total urinary pyridinolines.
Intact parathyroid hormone concentrations were significantly higher in subjects with the AA genotype, with a trend toward higher values in those with the BB and tt genotypes as well. (...)
Mots-clés Pascal : Densité, Elément minéral, Os, Métabolisme, Postménopause, Latinoaméricain, Etats Unis, Amérique du Nord, Amérique, Origine ethnique, Récepteur biologique, Vitamine D, Polymorphisme, Génétique population, Système ostéoarticulaire, Homme, Femelle, Mexicain
Mots-clés Pascal anglais : Density, Inorganic element, Bone, Metabolism, Postmenopause, Latinamerican, United States, North America, America, Ethnic origin, Biological receptor, Vitamin D, Polymorphism, Population genetics, Osteoarticular system, Human, Female
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0245808
Code Inist : 002A23A. Création : 11/06/1997.