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  1. Alcohol consumption and serum liver-derived enzymes in a Danish population aged 30-50 years.

    Article - En anglais

    Background

    Based on the increased consumption of alcohol in Denmark the aim of this study was to measure prevalence of abnormal liver-derived enzymes in a homogeneous Danish population and possible associations with alcohol consumption, smoking and body mass index (BMI).

    Method

    In a representative population sample of 905 people (aged 30-50) from the baseline survey of the Ebeltoft Health Promotion Project in Denmark, we examined prevalence of abnormal liver-derived enzymes and its possible association with self-reported alcohol consumption, smoking and BMI, applying logistic regression analyses.

    Results

    In a significant proportion, 12% (women 8% ; men 16%) of the cohort we found raised levels of liver-derived enzymes associated with moderate self-reported alcohol intake adjusted for BMI and smoking.

    If the intake was higher than moderate, i.e.>28 units per week (one unit equals 12 g of alcohol), the odds ratio (OR) for raised liver enzymes increased further ; S-gamma-glutamyltransferase (GGT) (OR : for women 24.4 ; men 18.4), S-aspartate-aminotransferase (ASAT) (24.2 ; 5.8) and S-alanine-aminotransferase (ALAT) (27.2 ; 3.0).

    Furthermore, daily smoking increased the risk of raised liver enzymes in women (OR : 3.4-4.2), and obesity (BMI = 30 kg/m2) in men showed a positive association with all three enzymes (OR : 3.0-9.0).

    Conclusions

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    Mots-clés Pascal : Consommation alimentaire, Boisson alcoolisée, Ethanol, Indice masse corporelle, Tabagisme, Association, Enzyme, Foie, Plasma sanguin, Prévalence, Taux, Facteur risque, Homme, Danemark, Europe, Epidémiologie, Toxicité, Appareil digestif

    Mots-clés Pascal anglais : Food intake, Alcoholic beverage, Ethanol, Body mass index, Tobacco smoking, Association, Enzyme, Liver, Blood plasma, Prevalence, Rate, Risk factor, Human, Denmark, Europe, Epidemiology, Toxicity, Digestive system

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0244937

    Code Inist : 002B30A01A2. Création : 11/06/1997.