Based on the increased consumption of alcohol in Denmark the aim of this study was to measure prevalence of abnormal liver-derived enzymes in a homogeneous Danish population and possible associations with alcohol consumption, smoking and body mass index (BMI).
In a representative population sample of 905 people (aged 30-50) from the baseline survey of the Ebeltoft Health Promotion Project in Denmark, we examined prevalence of abnormal liver-derived enzymes and its possible association with self-reported alcohol consumption, smoking and BMI, applying logistic regression analyses.
In a significant proportion, 12% (women 8% ; men 16%) of the cohort we found raised levels of liver-derived enzymes associated with moderate self-reported alcohol intake adjusted for BMI and smoking.
If the intake was higher than moderate, i.e.>28 units per week (one unit equals 12 g of alcohol), the odds ratio (OR) for raised liver enzymes increased further ; S-gamma-glutamyltransferase (GGT) (OR : for women 24.4 ; men 18.4), S-aspartate-aminotransferase (ASAT) (24.2 ; 5.8) and S-alanine-aminotransferase (ALAT) (27.2 ; 3.0).
Furthermore, daily smoking increased the risk of raised liver enzymes in women (OR : 3.4-4.2), and obesity (BMI = 30 kg/m2) in men showed a positive association with all three enzymes (OR : 3.0-9.0).
Mots-clés Pascal : Consommation alimentaire, Boisson alcoolisée, Ethanol, Indice masse corporelle, Tabagisme, Association, Enzyme, Foie, Plasma sanguin, Prévalence, Taux, Facteur risque, Homme, Danemark, Europe, Epidémiologie, Toxicité, Appareil digestif
Mots-clés Pascal anglais : Food intake, Alcoholic beverage, Ethanol, Body mass index, Tobacco smoking, Association, Enzyme, Liver, Blood plasma, Prevalence, Rate, Risk factor, Human, Denmark, Europe, Epidemiology, Toxicity, Digestive system
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0244937
Code Inist : 002B30A01A2. Création : 11/06/1997.