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  1. Serum sialic acid and its correlates in community samples from Akita, Japan and Minneapolis, USA.

    Article - En anglais

    Objective

    The concentration of serum total sialic acid (S-TSA) is one recently investigated risk marker for cardiovascular mortality and atherosclerosis.

    Since the mortality from coronary heart disease is higher in the United States than in Japan, one could expect the S-TSA to be higher among Caucasian US citizens than among Japanese citizens, a hypothesis that is tested in this study.

    Design

    Cross-sectional study of population-based samples of Japanese and US Caucasian men and women.

    Setting

    The rural community Akita, Japan, and the suburbs of Minneapolis, Minnesota.

    Subjects

    These were 75 consecutive men and women from Akita and Minneapolis respectively aged 47-69 years in 1990.

    People who had smoked cigarettes during the past 5 years ; who had a history of diabetes mellitus, liver disease, coronary heart disease, or stroke ; or who were taking anticoagulants were excluded.

    Outcome Measures

    Serum total sialic acid levels in male and female Japanese and US Caucasian subjects with adjustment for age, systolic blood pressure, fibrinogen, triglycerides and in women also for menopausal status.

    Race and sex-specific correlations with serum total sialic acid for selected cardiovascular risk markers.

    Results

    The entire sialic acid distributions were shifted to the right in Caucasian men and women compared to Japanese men and women.

    The mean ± standard deviation concentrations of S-TSA were 54.1 ± 5.3 mg/dl in Japanese men and 58.7 ± 5.6 mg/dl in Caucasian men (P<0. (...)

    Mots-clés Pascal : Cardiopathie coronaire, Sialique acide, Plasma sanguin, Epidémiologie, Risque, Marqueur biologique, Homme, Etats Unis, Amérique du Nord, Amérique, Japon, Asie, Etude comparative, Appareil circulatoire pathologie

    Mots-clés Pascal anglais : Coronary heart disease, Sialic acid, Blood plasma, Epidemiology, Risk, Biological marker, Human, United States, North America, America, Japan, Asia, Comparative study, Cardiovascular disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0244927

    Code Inist : 002B12A03. Création : 11/06/1997.