Malignant and benign tumors of the salivary glands have been associated with exposure to ionizing radiation from various sources, including the atomic bombings in Hiroshima and Nagasaki.
However, questions remain unanswered regarding the nature and size of the risk and specific types of tumors involved.
The incidence and pathology of malignant and benign tumors of the salivary glands was studied in the Life Span Study cohort of atomic bomb survivors followed by the Radiation Effects Research Foundation (RERF) in Hiroshima and Nagasaki, Japan.
Incident cases diagnosed during the period 1950-1987 were ascertained from the tumor and tissue registries of Hiroshima and Nagasaki and supplemented by additional case findings from autopsy, biopsy, and surgical specimens maintained at RERF and other institutions.
Pathology slides and medical documents were reviewed by a panel of four pathologists who classified tumors using the World Health Organization classification scheme.
Analyses were performed of histologic features associated with radiation exposure.
Of 145 tumors of the salivary glands identified (119 of the major and 26 of the minor salivary glands), 120 (83%) were histologically confirmed by the current investigators.
Among 41 malignant tumors, the frequency of mucoepidermoid tumor was disproportionately high at high radiation doses (P=0. (...)
Mots-clés Pascal : Tumeur maligne, Tumeur bénigne, Glande salivaire, Carcinogenèse, Facteur risque, Homme, Irradiation ionisante, Explosion nucléaire, Survivant, Epidémiologie, Incidence, Etude cohorte, Japon, Asie, Stomatologie, Glande salivaire pathologie
Mots-clés Pascal anglais : Malignant tumor, Benign neoplasm, Salivary gland, Carcinogenesis, Risk factor, Human, Ionizing irradiation, Nuclear explosion, Survivor, Epidemiology, Incidence, Cohort study, Japan, Asia, Stomatology, Salivary gland disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0244545
Code Inist : 002B10B01. Création : 11/06/1997.