Nocardia species are ubiquitous in the environment and may be found in the soil.
They are generally responsible for sporadic pulmonary diseases acquired by inhalation of spores, with secondary localizations in the central nervous system and subcutaneous tissues.
There is no absolute evidence for person to person transmission.
Presumptive outbreaks of nocardiosis were observed in immunocompromised patients, more frequently in kidney transplant patients than in cardiac transplant patients.
Nocardia spp., being present in dust particles, closure and disinfection of the transplantation unit with formaldehyde arrested the sequence of cases of nocardiosis.
The original sources of the Nocardia sp. remain doubtful.
Other possible sources of contamination are other patients, medical staff and the hospital environment.
The first studies of Nocardia spp. typing were based on the detection of extracellular antigens, on the susceptibility of actinomycete strains to killer yeasts, and on the biochemical profiles with fluorogenic substrate.
The use of molecular typing techniques have given very promising results.
Analysis of plasmid profiles is an interesting way to compare the identity of isolates, although the reliability of this method depends of the presence of plasmids in the isolates. (...)
Mots-clés Pascal : Nocardiose, Actinomycose, Bactériose, Infection, Poumon, Epidémiologie, Nocardia, Nocardiaceae, Actinomycetales, Actinomycetes, Bactérie, Typage, Sérotypie, Diagnostic, Biologie moléculaire, Appareil respiratoire pathologie, Poumon pathologie
Mots-clés Pascal anglais : Nocardiosis, Actinomycosis, Bacteriosis, Infection, Lung, Epidemiology, Nocardia, Nocardiaceae, Actinomycetales, Actinomycetes, Bacteria, Typing, Serotyping, Diagnosis, Molecular biology, Respiratory disease, Lung disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0243392
Code Inist : 002B05B02E. Création : 11/06/1997.