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  1. Orthostatic hypotension and low blood pressure in organic dementia : A study of prevalence and related clinical characteristics.

    Article - En anglais


    To determine the prevalence of orthostatic hypotension (OH), low blood pressure and dizziness, falls and fractures in patients with organic dementia.


    We prospectively studied 151 patients, assessing the prevalence of OH, hypertension, heart disorders, diabetes mellitus and the use of medication possibly associated with OH.


    The patients were admitted to our psychogeriatric clinic as part of routine clinical investigation of their dementia.


    Forty-six patients with Alzheimer's disease (AD), 28 patients with frontotemporal dementia (FTD) and 77 patients with vascular dementia (VaD) were investigated.

    Main outcome measure

    Due to the paucity of information about the prevalence of OH in organic dementia, this study is mainly explorative in nature, thus preventing explicit hypothesis formulation.

    However, clinical impressions indicated a higher prevalence of OH in organic dementia than normally seen in healthy elderly.


    OH/low blood pressure was present in 39-52% of the patients.

    The majority reached their maximum systolic decrease within 5 minutes of standing, but in 20-30% the maximum blood pressure drop occurred after 5 minutes or later.

    In 38%, the systolic blood pressure drop was more than 40 mmHg.

    Hypertension and heart disease was found only in AD and VaD, with no difference between those with and without OH/low blood pressure. (...)

    Mots-clés Pascal : Hypotension artérielle orthostatique, Pression sanguine, Hémodynamique, Vertige, Prévalence, Epidémiologie, Démence Alzheimer, Chute, Fracture, Démence vasculaire, Démence, Lobe frontal, Lobe temporal, Association morbide, Etude comparative, Vieillard, Homme, Appareil circulatoire pathologie, Système nerveux pathologie, Système nerveux autonome pathologie, ORL pathologie, Trouble équilibre, Système nerveux central pathologie, Encéphale pathologie, Maladie dégénérative, Cérébrovasculaire pathologie

    Mots-clés Pascal anglais : Postural hypotension, Blood pressure, Hemodynamics, Vertigo, Prevalence, Epidemiology, Alzheimer disease, Fall, Fracture, Vascular dementia, Dementia, Frontal lobe, Temporal lobe, Concomitant disease, Comparative study, Elderly, Human, Cardiovascular disease, Nervous system diseases, Diseases of the autonomic nervous system, ENT disease, Equilibrium disorder, Central nervous system disease, Cerebral disorder, Degenerative disease, Cerebrovascular disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0238557

    Code Inist : 002B17G. Création : 11/06/1997.