To study the association between Alzheimer's disease and smoking history.
An unmatched case-control study.
Psychogeriatric unit serving an elderly population of Warrington.
Period. 2 years 1991-1993.
198 cases of Alzheimer's disease (ADRDA-NINCDS diagnostic criteria) were compared to two selected control groups (164 other dementias and 176 non-dementing group) with respect to their smoking history.
Relative risk (odds ratio) of Alzheimer's disease.
The odds ratio for Alzheimer's disease in patients who smoked was 0.68 (95% CI 0.47-0.98).
The negative association was statistically significant only in male patients, OR 0.45 95% CI (0.23-0.87), p<0.05.
The inverse association was also only significant in patients with family history of dementia, OR 0.3495% CI (0.12-0.92), p<0.05.
The study supports previous findings of an inverse relationship between smoking and Alzheimer's disease.
This, however, does not suggest that smoking is used as a preventive measure for Alzheimer's disease.
Mots-clés Pascal : Démence Alzheimer, Antécédent, Tabagisme, Epidémiologie, Sexe, Vieillard, Homme, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Maladie dégénérative
Mots-clés Pascal anglais : Alzheimer disease, Antecedent, Tobacco smoking, Epidemiology, Sex, Elderly, Human, Nervous system diseases, Central nervous system disease, Cerebral disorder, Degenerative disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0237132
Code Inist : 002B17G. Création : 11/06/1997.