The distribution of hepatitis C virus (HCV) genotypes was determined in isolates of 447 chronically HCV-infected German patients by nucleotide sequencing.
Of these, 206 (46.1%) were infected with the subtype la, 215 (48.1%) with subtype 1b, 2 (0.4%) with subtype 1c, 9 (2.0%) with subtype 3a, and 15 (3.4%) with subtype 4a.
Subtype la was predominant in those<40 years old (62.6%) and was associated with the risk factor of intravenous drug addiction and with shorter duration of disease.
Conversely, subtype 1b was more frequent in patients>50 years old (84.7% ; P<. 001) and was associated with the risk factor of blood transfusions and with longer duration of disease.
These data suggest that a shift from subtype 1b to subtype la occurred in the population studied.
An increase in HCV infection with subtype la and a diminution of subtype 1b in the future can be expected.
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Effet biologique, Age, Phénotype, Virus hépatite C, Flaviviridae, Virus, Epidémiologie, Homme, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Biological effect, Age, Phenotype, Hepatitis C virus, Flaviviridae, Virus, Epidemiology, Human, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0237042
Code Inist : 002B05C02G. Création : 11/06/1997.