Evaluation of some biomonitoring markers in occupationally exposed populations to acrylonitrile.
In the present work we studied acrylonitrile (AN) occupationally exposed populations and respective control individuals working in a Portuguese plant producing acrylic textile fibers.
Three subgroups of individuals were considered : controls (C), workers of the continuous polymerization (CP) area, and workers of equipment maintenance (MM).
Besides aiming to contribut to a better understanding of the hazardous exposure of man to AN, the study aimed to help validate and optimize the use of a combination of methods applied to human populations exposed to genotoxic compounds.
Three main compartments related to the dose or effect of the hazardous compound were evaluated using various assessment methods : 1) internal dose (genotoxicity in urine, indicators of oxidative stress, induction of cytochromes P450) ; 2) biological effective dose (hemoglobin adducts) ; and 3) early biological effects (chromosomal aberrations, sister chromatid exchanges).
Although concern with exposure to AN has long been the subject of numerous studies, they have been carried out essentially in animals and using in vitro systems.
The significant differences (P<0.01) found in the chromosomal aberrations of MM are in agreement with the highly significant levels of hemoglobin adducts described in another study performed in the same population.
Hemoglobin adducts were also sensitive in detecting a hazardous exposure in the case of CP. (...)
Mots-clés Pascal : Acrylonitrile, Toxicité, Exposition professionnelle, Médecine travail, Homme, Industrie textile, Surveillance biologique, Marqueur biologique, Urine, Liquide biologique, Cytochrome P450, Peroxydation, Lipide, Echange chromatide soeur, Hémoglobine, DNA, Portugal, Europe, Aberration chromosomique, Cytogénétique, Adduit moléculaire
Mots-clés Pascal anglais : Acrylonitrile, Toxicity, Occupational exposure, Occupational medicine, Human, Textile industry, Biological monitoring, Biological marker, Urine, Biological fluid, Cytochrome P450, Peroxidation, Lipids, Sister chromatid exchange, Hemoglobin, DNA, Portugal, Europe, Chromosomal aberration, Cytogenetics, Molecular adduct
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0235259
Code Inist : 002B03L06. Création : 11/06/1997.