Cardiovascular morbidity and mortality in patients with seropositive rheumatoid arthritis in Northern Sweden.
To investigate the overall and the cardiovascular mortality in rheumatoid arthritis (RA) in Northern Sweden.
To analyze the effect of traditional risk factors and factors associated with rheumatoid disease and its treatment on the progression of cardiovascular disease (CVD) and on mortality by all causes.
A cohort of 606 patients with seropositive RA were followed from 1979 to the end of 1994 or to the death of the patient.
Standardized mortality ratio and survival curves were estimated with the population of Västerbotten as reference.
Sex, age at disease onset, treatment with corticosteroids, use of disease modifying antirheumatic drugs (DMARD) and hormone replacement therapy (HRT), hypertension, diabetes mellitus, HLA types, and cause of death were recorded from disease onset.
Cox's proportional hazards regression was used to identify important predictors for death and cardiovascular event during followup.
The standardized mortality ratio in both sexes was significantly higher (1.57) for all underlying causes together, for CVD (1.46) and for ischemic heart disease (IHD) (1.54) compared to the reference population.
The death rate increased over time.
In multiple Cox regression analyses, male sex, higher age at disease onset, and former cardiovascular event increased the death rate.
Male sex, high age at disease onset, and hypertension increased the risk of cardiovascular event. (...)
Mots-clés Pascal : Polyarthrite rhumatoïde, Facteur rhumatoïde, Traitement, Epidémiologie, Morbidité, Mortalité, Appareil circulatoire pathologie, Facteur prédictif, Facteur risque, Suède, Europe, Homme, Chronique, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire, Immunopathologie, Maladie autoimmune
Mots-clés Pascal anglais : Rheumatoid arthritis, Rheumatoid factor, Treatment, Epidemiology, Morbidity, Mortality, Cardiovascular disease, Predictive factor, Risk factor, Sweden, Europe, Human, Chronic, Diseases of the osteoarticular system, Inflammatory joint disease, Immunopathology, Autoimmune disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0235104
Code Inist : 002B15D. Création : 11/06/1997.