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  1. Consequences of high-dose steroid therapy for acute spinal cord injury.

    Article, Communication - En anglais

    Annual Meeting of the American Association for the Surgery of Trauma. Halifax, Nova Scotia (CAN), 1995/09/27.


    High-dose Solu-Medrol (Upjohn, Kalamazoo, Mich) therapy has become standard care in the management of acute spinal cord injury (ASCI).

    This study attempts to define the adverse effects that Solu-Medrol therapy has on these patients.


    Retrospective review with historical control.

    Material and Methods 

    From May 1990 to April 1994, all patients with ASCI admitted within 8 hours of injury received high-dose Solu-Medrol per the National Acute Spinal Injury Study (NASCIS-2) protocol.

    Their demographic and outcome parameters were compared with those of a group admitted from March 1986 to December 1993 with an associated ASCI who received no steroid therapy.

    Measurements and Main Results 

    Steroid therapy was associated with a 2.6-fold increase in the incidence of pneumonia and an increase in ventilated and intensive care days.

    However, it was associated with a decrease in duration of rehabilitation and had no significant impact on other outcome parameters, including mortality.


    Although the NASCIS-2 protocol may promote early infectious complications, it has no adverse impact on long-term outcome in patients with ASCIs.

    Mots-clés Pascal : Traumatisme, Moelle épinière, Traitement, Stéroïde, Chimiothérapie, Dose forte, Epidémiologie, Complication, Incidence, Unité soin intensif, Hospitalisation, Pronostic, Pneumonie, Homme, Système nerveux pathologie, Système nerveux central pathologie, Moelle épinière pathologie, Appareil respiratoire pathologie, Poumon pathologie

    Mots-clés Pascal anglais : Trauma, Spinal cord, Treatment, Steroid, Chemotherapy, High dose, Epidemiology, Complication, Incidence, Intensive care unit, Hospitalization, Prognosis, Pneumonia, Human, Nervous system diseases, Central nervous system disease, Spinal cord disease, Respiratory disease, Lung disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0234184

    Code Inist : 002B16B. Création : 11/06/1997.