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  1. Adjuvant chemotherapy (5-fluorouracil and levamisole) in Dukes'B and C colorectal carcinoma. A cost-effectiveness analysis.

    Article - En anglais


    Adjuvant chemotherapy (5-fluorouracil, levamisole) is now standard practice in the treatment of Dukes'B and C coloretal carcinoma (CRC), and this has increased the financial burden on health care systems world-wide.

    Patients and methods 

    Between 1993 and 1996,95 patients in northern Norway were included in a national randomised CRC study, and assigned to surgery plus adjuvant chemotherapy or surgery alone.

    In April 1996,94 of the patients were evaluable and 82 were still alive.

    The total treatment costs (hospital stay, surgery, chemotherapy, administrative and travelling costs) were calculated.

    A questionnaire was mailed to all survivors for assessment of the quality of their lives (QoL) (EuroQol questionnaire, a simple QoL-scale, global QoL-measure of the EORTC QLQ-C30), and 62 of them (76%) responded.


    Adjuvant chemotherapy in Dukes'B and C CRC raised the total treatment costs by £ 3,360.

    The median QoL was 0.83 (0-1 scale) in both arms.

    Employing a 5% discount rate and an improved survival of adjuvant therapy ranging from 5% to 15%, we calculated the cost of one gained quality-adjusted life-year (QALY) to be between £4,800 and £16,800.


    Using a cut-off point level of £20,000 per QALY, adjuvant chemotherapy in CRC appears to be cost-effective only when the improvement in 5-year survival is = 5%. Adjuvant chemotherapy does not affect short-term QoL.

    Mots-clés Pascal : Fluorouracil, Lévamisole, Association médicamenteuse, Carcinome, Côlon, Rectum, Chimiothérapie, Traitement adjuvant, Chirurgie, Homme, Analyse coût efficacité, Norvège, Europe, Anticancéreux, Stade avancé, Fluoropyrimidine dérivé, Tumeur maligne, Intestin pathologie, Côlon pathologie, Rectum pathologie

    Mots-clés Pascal anglais : Fluorouracil, Levamisole, Drug combination, Carcinoma, Colon, Rectum, Chemotherapy, Adjuvant treatment, Surgery, Human, Cost efficiency analysis, Norway, Europe, Antineoplastic agent, Advanced stage, Fluoropyrimidine derivatives, Malignant tumor, Intestinal disease, Colonic disease, Rectal disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0234082

    Code Inist : 002B02R02. Création : 11/06/1997.