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  1. Factors influencing short-term and long-term pediatric renal transplant survival.

    Article - En anglais

    Objective 

    To determine the patient and donor characteristics important for short-term and long-term renal transplant survival at Cincinnati Children's Hospi tal Medical Center.

    Methods 

    Cumulative transplant survival was calculated and univariate analysis of graft survival performed on 206 transplants done since 1970 in 148 pediatric patients.

    Grafts to black recipients were analyzed separately.

    Short-term graft survival is defined as 1-year allograft survival and long-term graft survival as graft half-life (t1/2) survival for allografts functioning after the first positransplant year.

    Results 

    One-year graft survival of living-related donor (LRD) and cadaver donor (CAD) transplants was 77% and 62%, respectively.

    Graft t1/2 was 11.2 years for LRD and 9.8 years for CAD grafts.

    The CAD 1-year graft survival when the recipient or donor was younger than 7 years was 36% and 41%, respectively.

    The LRD 1-year graft survival to children younger than 7 years was 88% versus 75% in older children.

    Graft survival at 1 year was similar for CAD primary and retransplants (60% vs 65%), but graft t1/2 better for CAD primary grafts (17.8 years vs 5.0 years, p<0.001).

    Preemptive LRD grafts performed similarly at 1 year and better over the long term compared with patients who had long-term dialysis (85% vs 74%, p=NS ; and 16.9 years vs 8.0 years, p<0.001).

    Preemptive CAD grafts did poorly, with 1 - year graft survival of 38%. (...)

    Mots-clés Pascal : Homotransplantation, Rein, Facteur risque, Survie, Enfant, Homme, Transplantation, Chirurgie, Rein pathologie, Appareil urinaire pathologie

    Mots-clés Pascal anglais : Homotransplantation, Kidney, Risk factor, Survival, Child, Human, Transplantation, Surgery, Kidney disease, Urinary system disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0233912

    Code Inist : 002B25H. Création : 11/06/1997.