Prognostic significance of non-gastric malignancy after treatment of early gastric cancer.
Background The recurrence rate of early gastric cancer is low and so second malignancies developing after treatment of this cancer have potential prognostic significance.
Methods Some 633 patients with early gastric cancer were studied.
The median observation time was 123 months.
To examine the characteristics of patients with early gastric cancer and subsequent malignancy, two groups of patients, those with and those without non-gastric malignancy, were compared using univariate analysis with respect to various clinicopathological factors.
To determine which parameters were independently significant, computer-based multivariate discriminant function analysis was applied.
To estimate the prognostic significance of non-gastric malignancy, death rates from these diseases in patients treated for early gastric cancer were compared with the mortality rates attributable to the same diseases in the general population of Japan.
Results The frequency of other malignancies, 9.6 per cent (61 of 633), was significantly higher than the gastric cancer recurrence rate of 2.4 per cent (15 of 633).
After treatment for early gastric cancer patients with subsequent non-gastric malignancy had a significantly poorer outcome than those free from other cancers.
Lung cancers were the major neoplasms occurring after the treatment of early gastric cancer. (...)
Mots-clés Pascal : Carcinome, Estomac, Stade précoce, Traitement, Incidence, Second cancer, Pronostic, Etude comparative, Homme, Japon, Asie, Tumeur maligne, Appareil digestif pathologie, Estomac pathologie
Mots-clés Pascal anglais : Carcinoma, Stomach, Early stage, Treatment, Incidence, Second cancer, Prognosis, Comparative study, Human, Japan, Asia, Malignant tumor, Digestive diseases, Gastric disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0229702
Code Inist : 002B13B01. Création : 11/06/1997.