Interpretation of data from multiple trials : a critical review.
The objective was to review the current status of meta-analysis, the process of combining the results of similar investigations, which was described in 1976.
It has evolved rapidly, and thousands have already been published.
Meta-analysis may be performed in a narrative form or in the preferred statistical format, which is more rigorous and demanding.
The criteria for designing and performing a meta-analysis of high quality are presented and discussed in detail, including selection criteria, quality, biases and heterogeneity, both of component studies and of results.
Critical reviews of meta-analyses are presented.
Examples are given from my own field - hepatology - and from my own research experience.
Although meta-analysis is simple in concept, it is complex in execution.
If performed with insufficient insight or attention to detail, it may give ambiguous or erroneous results.
Mots-clés Pascal : Métaanalyse, Critère décision, Critère performance, Interprétation, Donnée observation, Multiple, Essai, Méthodologie, Critère qualité, Analyse statistique, Evaluation, Responsabilité professionnelle, Article synthèse, Homme, Politique sanitaire, Organisation santé
Mots-clés Pascal anglais : Metaanalysis, Decision criterion, Performance requirement, Interpretation, Observation data, Multiple, Test, Methodology, Quality criterion, Statistical analysis, Evaluation, Occupational responsibility, Review, Human, Health policy, Public health organization
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0229154
Code Inist : 002B30A11. Création : 11/06/1997.