The prognosis of chronic fatigue syndrome and chronic fatigue has been studied in numerous small case series.
We performed a systematic review of all studies to determine the proportion of individuals with the conditions who recovered at follow-up, the risk of developing alternative physical diagnoses, and the risk factors for poor prognosis.
A literature search of all published studies which included a follow-up of patients with chronic fatigue syndrome or chronic fatigue were performed.
Of 26 studies identified, four studied fatigue in children, and found that 54-94% of children recovered over the periods of follow-up.
Another five studies operationally defined chronic fatigue syndrome in adults and found that<10% of subjects return to pre-morbid levels of functioning, and the majority remain significantly impaired.
The remaining studies used less stringent criteria to define their cohorts.
Among patients in primary care with fatigue lasting<6 months, at least 40% of patients improved.
As the definition becomes more stringent the prognosis appears to worsen.
Consistently reported risk factors for poor prognosis are older age, more chronic illness, having a comorbid psychiatric disorder and holding a belief that the illness is due to physical causes.
Mots-clés Pascal : Fatigue chronique syndrome, Diagnostic différentiel, Fatigue, Dépistage, Critère sélection, Etiologie, Facteur risque, Synthèse bibliographique, Etude comparative, Facteur prédictif, Evaluation, Homme, Enfant, Système nerveux pathologie
Mots-clés Pascal anglais : Chronic fatigue syndrome, Differential diagnostic, Fatigue, Medical screening, Selection criterion, Etiology, Risk factor, Bibliographic survey, Comparative study, Predictive factor, Evaluation, Human, Child, Nervous system diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0229123
Code Inist : 002B18C14. Création : 11/06/1997.