Objectives This investigation attempted to follow the tubular function of 46 workers initially examined in 1984 and heavily exposed to cadmium from 1955 to 1978 and the occurrence of renal stones among these workers.
Three different markers of tubular dysfunction were also studied, and blood cadmium was evaluated as an estimate of dose after the cessation of cadmium exposure.
Methods Cadmium in blood (B-Cd) and urine (U-Cd) and the urinary excretion of bêta2-microglobulin (U-bêta2-microglobulin), protein HC (alpha1-microglobulin) and N-Acetyl-bêta-D-glucosaminidase (NAG) were determined.
Results Although cadmium exposure ceased in 1978,40% of the workers showed signs of tubular dysfunction both in 1984 and in 1993.
The current B-Cd was the best dose indicator.
Dose-response relationships were found for B-Cd and various tubular markers (U-bêta2-microglobulin, protein HC and NAG).
Protein HC appeared to be the most sensitive, as well as an early, indicator of cadmium-induced tubular dysfunction.
The levels of U-Cd had an average decrease of 48% for persons with a normal tubular function, 56% for those with slight tubular dysfunction, and 62% for workers with severe tubular damage.
A history of renal stones was significantly more common for workers with high B-Cd levels.
Conclusions Cadmium-induced tubular dysfunction is irreversible and best assessed in an analysis of protein HC (alpha1-microglobulin) in urine. (...)
Mots-clés Pascal : Cadmium, Calcul urinaire, Métal lourd, Toxicité, Exposition professionnelle, Médecine travail, Homme, Antécédent, Marqueur biologique, Surveillance biologique, Etude longitudinale, Sang, Liquide biologique, Urine, Microglobuline bêta2, Appareil urinaire pathologie, Tube rénal, Rein, bêta-N-Acetylhexosaminidase, O-Glycosidases, Glycosidases, Hydrolases, Enzyme, Histoire professionnelle, Microglobuline alpha1
Mots-clés Pascal anglais : Cadmium, Urinary stone, Heavy metal, Toxicity, Occupational exposure, Occupational medicine, Human, Antecedent, Biological marker, Biological monitoring, Follow up study, Blood, Biological fluid, Urine, bêta2-Microglobulin, Urinary system disease, Renal tubule, Kidney, bêta-N-Acetylhexosaminidase, O-Glycosidases, Glycosidases, Hydrolases, Enzyme
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0228234
Code Inist : 002B03L05. Création : 11/06/1997.