Coeliac disease is diagnosed by means of jejunal biopsy, an invasive procedure.
Anti-gliadin antibodies (AGA) have therefore been used in the first screening of the disease.
On the other hand, low titers of AGA are widely detected also in normal subjects.
In order to investigate if low levels of AGA could be correlated with laboratory and clinical data, we performed a study on 167 subjects with various illnesses, such as recurrent abdominal pain, failure to thrive, short stature, diarrhoea or constipation, cow-milk protein intolerance and/or food allergy, recurrent vomiting or previous gastroenteritis, all non coeliac conditions which have been associated with AGA presence.
Seventy coeliac children, all biopsied, were selected as a control group.
Among the 167 cases we found 60 subjects positive for AGA (35.9%), a high proportion as compared with the general population.
Only 33/167 patients, all IgG and IgA AGA positive, fulfil our laboratory and clinical criteria to perform a'confirming'biopsy.
For the 134 residual cases (14 IgA, 13 only IgG AGA positive, 107 AGA negative) a diagnosis of coeliac disease has been excluded by clinical criteria (scoring).
As a whole, the patients with coeliac disease had significantly higher levels of AGA of both IgG and IgA classes (p<0.01).
On the other hand, no significant difference emerged for all the anamnestic and laboratory parameters considered between AGA+and AGA-non-coeliac subjects. (...)
Mots-clés Pascal : Coeliaque maladie, Gliadine, Anticorps, Sérologie, Etude comparative, Diagnostic, Evaluation performance, Technique, Enfant, Homme, Méthode non invasive, Epidémiologie, Appareil digestif pathologie, Intestin pathologie, Malabsorption intestinale, Immunopathologie
Mots-clés Pascal anglais : Coeliac disease, Gliadin, Antibody, Serology, Comparative study, Diagnosis, Performance evaluation, Technique, Child, Human, Non invasive method, Epidemiology, Digestive diseases, Intestinal disease, Intestinal malabsorption, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0227507
Code Inist : 002B13B03. Création : 11/06/1997.