logo BDSP

Base documentaire


Votre avis nous intéresse

Le réseau BDSP met en oeuvre un projet d'innovation et d'amélioration de ses services, dans le souci constant de proposer des contenus de qualité adaptés aux besoins des utilisateurs.

Identifier de nouvelles sources de financements est la condition nécessaire pour assurer la poursuite et la pérennité de cet outil unique qu'est la BDSP, tout en le faisant évoluer.

Pour définir un nouveau modèle économique, nous avons besoin de votre avis : merci de répondre à notre enquête (temps estimé : 5 minutes).

Participer maintenant
Participer plus tard J'ai déjà participé

  1. Prevalence of hepatitis C virus genotypes in southern Italy.

    Article - En anglais

    HCV is ubiquitous.

    In 50% of all cases it causes chronic hepatitis that often evolves into liver cirrhosis and hepatocellular carcinoma.

    Recently HCV has been classified in 5 genotypes by Okamoto.

    The purpose of this study is to evaluate the prevalence of 5 genotypes in Campania, a region of southern Italy, where the prevalence of anti-HCV antibodies ranges from 0.87 to 4%, and to evaluate the correlation between the HCV genotypes and the severity of histological damage.

    One-hundred-and-thirty-five anti-HCV positive patients were enrolled and tested by PCR to identify HCV-RNA.

    One-hundred-and-twenty-four patients resulted HCV-RNA positive.

    Genotyping was performed as described by Okamoto et al. with minor modifications of the specific primer to type III proposed by Silini et al.

    Eight patients were negative for all genotypes.

    Eight patients were positive for type I (la), 61 for type II (lb), 39 for type III (2a), 11 for type IV (2b) and 1 for type V (3a).

    In 4 cases two different genotypes were present in the same sample [II (1b) - IV (2b), III (2a) - II (1b) twice, III (2a) - IV (2b) ]. Histological evaluation of liver damage showed : CPH (22 cases), minimal CAH (56), severe CAH (31) and liver cirrhosis (15).

    There was no statistically significant correlation between the 5 genotypes and the severity of histological damage.

    Data on the prevalence of genotype II (lb) in Italy are similar to those reported for other European countries. (...)

    Mots-clés Pascal : Hépatite virale C, Virose, Infection, Génotype, Virus hépatite C, Flaviviridae, Virus, Répartition géographique, Réaction chaîne polymérase, Epidémiologie, Prévalence, Facteur risque, Indice gravité, Homme, Italie, Europe, Appareil digestif pathologie, Foie pathologie, Biologie moléculaire

    Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Genotype, Hepatitis C virus, Flaviviridae, Virus, Geographic distribution, Polymerase chain reaction, Epidemiology, Prevalence, Risk factor, Severity score, Human, Italy, Europe, Digestive diseases, Hepatic disease, Molecular biology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0227506

    Code Inist : 002B05C02G. Création : 11/06/1997.