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  1. The rise of tamoxifen : Temporal and geographical trends of tamoxifen use in Ontario.

    Article - En anglais


    To describe the change in use of tamoxifen over time and across countries in Ontario.


    Data from the Ontario Drug Benefit (ODB) plan, Census Canada, and the Ontario Cancer Registry (OCR) were combined and analysed to determine rates of tamoxifen use for females over 65 for each county and the province overall, by year.

    Rates were analyzed by repeated measures ANOVA to determine significance of changes over time.

    Consistency of tamoxifen use across counties was determined by the Spearman rank correlation coefficient, and overall variation between counties was described using three statistical techniques : Chi-square analysis, the extremal quotient (EQ), and the systematic component of variation (SCV).


    The number of one-month tamoxifen prescriptions per incident case of breast cancer rose significantly from 13.51 in 1985 to 20.54 in 1990 (p<0.001) and to 34.06 in 1992 (p=0.001).

    Viewed differently, the number of women over 65 receiving tamoxifen prescriptions per incident case of breast cancer changed from 1.91 in 1985 to 3.14 in 1990 to 4.54 in 1992.

    Statistically significant variation in the rate of tamoxifen prescribing was demonstrated between Ontario counties in all three years by Chi Squared analysis (p<0.0001).

    Both the EQ and the SCV declined from 1985 to 1990, suggesting more uniform prescribing across the province.

    Little change in overall variation was seen between 1990 and 1992. (...)

    Mots-clés Pascal : Tamoxifène, Voie orale, Epidémiologie, Chimiothérapie, Tumeur maligne, Glande mammaire, Homme, Femelle, Traitement, Ontario, Canada, Amérique du Nord, Amérique, Analyse statistique, Composé non stéroïde, Antioestrogène, Glande mammaire pathologie, Consommation, Variation géographique

    Mots-clés Pascal anglais : Tamoxifene, Oral administration, Epidemiology, Chemotherapy, Malignant tumor, Mammary gland, Human, Female, Treatment, Ontario, Canada, North America, America, Statistical analysis, Non steroid compound, Antiestrogen, Mammary gland diseases, Consumption, Geographical variation

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0226825

    Code Inist : 002B02R02. Création : 11/06/1997.