Differential contribution of current and cumulative indices of lead dose to neuropsychological performance by age.
Article abstract-We examined measures of lead dose that reflect intensity of exposure and cumulative exposure for differential association with neuropsychological functional domains and with neuropsychological performance by age.
Eighty active lead smelter workers assessed for verbal memory and visuomotoric skills had a mean (range) age of 44 (24-64) years, duration of employment of 20 (4-26) years, education of 8 (0-13) grades, current blood lead (B-Pb) of 26 mugPb dl-1 (13-43), working lifetime weighted average blood lead (TWA) of 42 mugPb dl-1 (17-57), working lifetime integrated blood lead (IBL) of 903 mugPb-yr dl-1 (81-1,436) and bone lead (bone-Pb) of 41 mugPb (g bone mineral) - 1 (-12-90).
Multiple linear regression after adjusting for age and education showed a significant amount of variance in verbal memory (Rey Auditory Verbal Learning Test and Verbal Paired Associates) explained only by measures of lead dose intensity, B-Pb, and TWA.
Visuomotoric ability (Grooved Pegboard [GP] and Digit Symbol) had significant variance accounted for by measures of both lead dose intensity, TWA, and of cumulative lead dose, IBL, and bone-Pb.
The relationship between bone-Pb and GP was curvilinear in older workers, with increasingly slower performance above a bone-Pb threshold of 20 mugPb (g bone mineral) - l. (...)
Mots-clés Pascal : Travailleur, Fonderie, Plomb, Test neuropsychologique, Sang, Dose cumulée, Exploration, Homme, Médecine travail
Mots-clés Pascal anglais : Worker, Foundry, Lead, Neuropsychological test, Blood, Cumulated dose, Exploration, Human, Occupational medicine
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0225781
Code Inist : 002B30B01A. Création : 11/06/1997.