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  1. Quantitative studies of the risk of serious hepatic injury in persons using nonsteroidal antiinflammatory drugs.

    Article - En anglais

    Objective

    To quantify the risk of symptomatic hepatic injury associated with nonsteroidal antiinflammatory drugs (NSAIDs).

    Methods

    Five population-based studies were summarized to evaluate information on more than 1,000,000 patients using NSAIDS.

    Results

    The risk of clinically apparent liver injury was ~ case per 10,000 patient-years of NSAID use.

    Only sulindac, associated with a 5-10-fold higher incidence of hepatic injury, differed significantly from other NSAIDs.

    Patients using diclofenac showed no higher incidence of serious liver disease than did patients using other NSAIDs.

    Conclusion

    Symptomatic hepatic effects attributable to most NSAIDS are extremely rare and usually mild.

    Mots-clés Pascal : Antiinflammatoire non stéroïde, Traitement, Toxicité, Foie pathologie, Symptomatologie, Analyse quantitative, Epidémiologie, Facteur risque, Incidence, Homme, Appareil digestif pathologie, Trouble hépatique

    Mots-clés Pascal anglais : Non steroidal antiinflammatory agent, Treatment, Toxicity, Hepatic disease, Symptomatology, Quantitative analysis, Epidemiology, Risk factor, Incidence, Human, Digestive diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0225074

    Code Inist : 002B02U04. Création : 11/06/1997.