Solvent blood concentrations and subnarcotic effects (inhibition of electrically evoked seizures) were measured in rats exposed to constant or fluctuating air concentrations of toluene or acetone.
A 4 hour exposure of resting rats to toluene at an air concentration of 1 and 2 mg/l, or to acetone at 4 and 10 mg/l, led to blood levels of 6.7 and 12.8 mg/l of toluene, or 183 and 520 mg/l of acetone : seizure inhibition amounted to 18% and 40%, or 10% and 50%, respectively.
Blood level and effect attained 1/2 of the final values after 40 min and 60 min of exposure to 2 mg/l toluene, respectively, and dropped to 1/2 70 min and 90 min after exposure cessation : respective values for acetone 10 mg/l were 80 and 120 min, and more than 4 hours.
A steep rise and a rapid drop was characteristic also for the course of blood level and effect during an exposure to fluctuating concentrations of toluene : ten minute fivefold jump in the air concentration induced a shortlasting seizure inhibition by more than 80% ; the curves for acetone were flat.
Mots-clés Pascal : Toluène, Acétone, Solvant, Exposition, Inhalation, Taux, Sang, Médecine travail, Effet biologique, Toxicité, Dosage, Rat, Rodentia, Mammalia, Vertebrata
Mots-clés Pascal anglais : Toluene, Acetone, Solvent, Exposure, Inhalation, Rate, Blood, Occupational medicine, Biological effect, Toxicity, Assay, Rat, Rodentia, Mammalia, Vertebrata
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0219233
Code Inist : 002B03L04. Création : 21/05/1997.