Estimates of the effectiveness of a whole-cell pertussis vaccine from an outbreak in an immunized population.
Pertussis has re-emerged as a public health problem in Canada in recent years, emphasizing concerns about the effectiveness of the currently licensed whole-cell vaccine.
Following a 1994 outbreak in Nova Scotia, we conducted a case-control study of 483 children aged<10 years to assess vaccine effectiveness.
Ninety-three percent of children aged 6 months and above had received three or more doses of vaccine, however, only 78% had received age-appropriate immunization.
Among children aged 4 years and more, vaccine effectiveness against laboratory-confirmed pertussis was 57% (95% CI, 23-77%) for age-appropriate immunization (five doses) vs partial or no immunization.
Vaccine effectiveness increased with increasing number of doses from 25% (95% CI, - 58-65%) for three or more doses to 55% (95% CI, - 15-83%) for five doses, compared with 0-2 doses.
Mots-clés Pascal : Bordetella pertussis, Bactérie, Coqueluche, Bactériose, Infection, Vaccin, Vaccination, Efficacité, Calendrier vaccination, Enfant, Homme, Nourrisson, Immunoprophylaxie, Canada, Amérique du Nord, Amérique
Mots-clés Pascal anglais : Bordetella pertussis, Bacteria, Whooping cough, Bacteriosis, Infection, Vaccine, Vaccination, Efficiency, Vaccination schedule, Child, Human, Infant, Immunoprophylaxis, Canada, North America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0217621
Code Inist : 002A05B12. Création : 21/05/1997.