Individual variability in lipoprotein cholesterol response to National Cholesterol Education Program Step 2 diets.
The effects of National Cholesterol Education Program (NCEP) Step 2 diets on plasma lipoprotein profiles in 72 men [mean (± SD) age : 44 ± 15 y, range : 19-81 y] and 48 women (mean age : 50 ± 21 y, range : 21-78 y) participating in five previously published studies were examined.
Subjects were placed on a baseline diet similar to an average American diet (35-41% total fat, 13-16% saturated fat, 31-45 mg cholesterol/MJ) and then on an NCEP Step 2 diet (18-29% total fat, 4-7% saturated fat, 11-20 mg cholesterol/MJ) under isoenergetic conditions.
All food and drink were provided.
Compared with the baseline diet, consumption of the NCEP Step 2 diets was associated with significant decreases in concentrations of low-density-lipoprotein (LDL) cholesterol (-18.9% and - 15.6%, respectively) and high-density-lipoprotein (HDL) cholesterol (-17.0% and - 11.2%, respectively) in both men and women.
Men with the apolipoprotein (apo) E 3,4 phenotype had a significantly greater decrease in LDL cholesterol (-24.2%) with the NCEP Step 2 diets than men with the apo E 3,3 phenotype (-17.7%). Men with the apo A-IV 1,2 phenotype tended to have less LDL cholesterol lowering (-12.8%) than men with the apo A-IV 1,1 phenotype (-19.6%), but this difference was not significant.
No differences were seen by apo E and A-IV phenotype in women. (...)
Mots-clés Pascal : Programme sanitaire, Recommandation alimentaire, Lipoprotéine, Cholestérol, Régime alimentaire, Age, Métabolisme, Alimentation, Lipide, Homme
Mots-clés Pascal anglais : Sanitary program, Dietary allowance, Lipoprotein, Cholesterol, Diet, Age, Metabolism, Feeding, Lipids, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0214205
Code Inist : 002B30A02A. Création : 21/05/1997.