Considerable evidence suggests that a high concentration of coagulation factor VII is a risk factor for ischemic heart disease.
Factor VII is known to be influenced by dietary fat and probably by dietary fiber in young and middle-aged people.
There are no data available in elderly people and the effects of different types of fat are unclear.
This study examines the relation of factor VII activity (factor VIIc) with dietary fat and fiber in The Rotterdam Study.
The Rotterdam Study is a population-based study among 7983 men and women aged = 55 y. Factor VIIc was measured in 3007 subjects (1730 women and 1277 men aged 67.3 ± 7.8 and 66.3 ± 7.0 y, respectively).
Measurements included cardiovascular risk factors and habitual diet was assessed by a semiquantitative food-frequency questionnaire.
Associations that were significant or nearly significant differed for some nutrients between men and women.
Total fat intake showed a direct association with factor VIIc only in women (bêta=0.1%/g ; 95% CI : 0.01,0.20).
Saturated fat intake was associated with factor VIIc in women (bêta=0.18%/g ; 95% CI : 0.001,0.36) and in men (bêta=0.11%/g ; 95% CI : - 0.06,0.27).
Monounsaturated fat was positively related to factor VIIc in women (bêta=0.17%/g ; 95% CI : - 0.05,0.39) and polyunsaturated fat was inversely associated with factor VIIc in men (bêta=-0.15%/g ; 95% CI : - 0.33,0.03).
Fiber intake was inversely associated with factor VIIc in both men (bêta=-0.31%/g ; 95% CI : - 0.57, - 0. (...)
Mots-clés Pascal : Régime alimentaire, Matière grasse, Fibre alimentaire, Proconvertine, Appareil circulatoire pathologie, Facteur risque, Nutrition, Athérosclérose, Thrombose, Ischémie, Myocarde, Alimentation, Lipide, Facteur coagulation, Vaisseau sanguin pathologie, Cardiopathie coronaire, Vieillard, Homme
Mots-clés Pascal anglais : Diet, Fat, Dietary fiber, Factor VII, Cardiovascular disease, Risk factor, Nutrition, Atherosclerosis, Thrombosis, Ischemia, Myocardium, Feeding, Lipids, Coagulation factor, Vascular disease, Coronary heart disease, Elderly, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0214192
Code Inist : 002B30A02A. Création : 21/05/1997.