In many African populations, the prevalences of both iron deficiency and malarial infection exceed 50%. The control of iron deficiency anemia is of urgent public health importance, but assessment of iron status in these contexts has been controversial because of the effects of malarial disease on common iron status indicators.
We assessed iron status in 3605 school children in Zanzibar by measuring hemoglobin, erythrocyte protoporphyrin (EP) and serum ferritin concentrations.
Malaria parasitemia was quantified by counting against leukocytes.
Iron deficiency was highly prevalent : 62.4% of hemoglobin concentrations were<110 g/L, 59.7% of EP values were>80 mumol/mol heme, and 41.5% of ferritin concentrations were<12 mug/L. Prevalence of Plasmodium falciparum parasitemia was 60.6%, but<1% of children had densities above 5000 parasites/muL blood.
Neither hemoglobin nor EP concentration was associated with malaria parasite density, but prevalence of abnormal values increased by ¾25% with parasite density.
Erythrocyte protoporphyrin and hemoglobin were strongly inversely related regardless of parasite density.
The relationship of EP to hemoglobin was slightly attenuated when parasite density exceeded 1000 parasites/muL blood.
Ferritin rose by 1.5 mug/L per 1000 parasites/muL for parasite densities>1000 parasites/muL, but the relationship of ferritin to hemoglobin or EP was strong even when parasite densities exceeded this cutoff. (...)
Mots-clés Pascal : Hémoglobine, Fer, Déficit, Ferritine, Protoporphyrine, Indicateur biologique, Paludisme, Protozoose, Parasitose, Infection, Anémie, Sang, Hémopathie, Enfant, Homme, Plasmodium falciparum, Sporozoa, Protozoa
Mots-clés Pascal anglais : Hemoglobin, Iron, Deficiency, Ferritin, Protoporphyrin, Biological indicator, Malaria, Protozoal disease, Parasitosis, Infection, Anemia, Blood, Hemopathy, Child, Human, Plasmodium falciparum, Sporozoa, Protozoa
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0213755
Code Inist : 002B19A01. Création : 21/05/1997.