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  1. The association of family size with atopy and atopic disease.

    Article - En anglais

    Background Studies in children have shown that family size is negatively associated with atopy and atopic disease.

    Objective :

    To describe the association of family size with atopy and atopic disease in young adults.

    Methods A randomly selected sample of 1159 men and women aged 20-44 years provided information on respiratory symptoms, hay fever and eczema.

    Blood samples were taken for assessment of total IgE and specific IgE to house dust mite, grass, cat, Cladosporium and birch.

    The association of family size and birth order with respiratory symptoms, atopy and total IgE was assessed by multiple logistic and linear regression.

    Results There was a negative association between family size and the reporting of'wheeze with breathlessness' (adjusted odds ratio for an increase of one sibling 0.85 ; 95% confidence interval 0.75-0.98), wheeze without a cold' (adjusted odds ratio for an increase of one sibling 0.85 ; 95% confidence interval 0.75-0.98) and'asthma attacks'in the last 12 months (adjusted odds ratio for an increase of one sibling 0.77 ; 95% confidence interval 0.61-0.97), current'hayfever and nasal allergies' (adjusted odds ratio for an increase of one sibling 0.84 ; 95% confidence interval 0.75-0.94) and sensitization to grass (adjusted odds ratio for an increase of one sibling 0.87 ; 95% confidence interval 0.76-0.99).

    Birth order was negatively associated with'hayfever and nasal allergies'only. (...)

    Mots-clés Pascal : Atopie, Dimension famille, Rhinite, Prévalence, Epidémiologie, Asthme, Angleterre, Grande Bretagne, Royaume Uni, Europe, Eczéma, Adulte jeune, Homme, Immunopathologie, Allergie, ORL pathologie, Nez pathologie, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Peau pathologie

    Mots-clés Pascal anglais : Atopy, Family size, Rhinitis, Prevalence, Epidemiology, Asthma, England, Great Britain, United Kingdom, Europe, Eczema, Young adult, Human, Immunopathology, Allergy, ENT disease, Nose disease, Respiratory disease, Obstructive pulmonary disease, Skin disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0209448

    Code Inist : 002B06C01. Création : 21/05/1997.