Lung cancer mortality in a cohort of workers employed at a cadmium recovery plant in the United States : an analysis with detailed job histories.
Objectives-To identify and measure any relations between occupational exposure to cadmium compounds (oxide, sulphide, and sulphate) and the risk of mortality from lung cancer.
Methods-The mortality experience of 571 male production workers from a cadmium recovery facility in the United States was investigated for the period 1940-82.
All study subjects were first employed in the period 1926-69 ; they had all been employed for at least six months between 1 January 1940 and 31 December 1969.
Newly abstracted detailed job histories for the period 1926-76 were combined with assessments of exposures to cadmium over time to develop individual estimates of cumulative exposure to cadmium (total exposure and exposures received both in the presence and absence of « high » exposures to arsenic trioxide).
Poisson regression was used to investigate risks of mortality from lung cancer in relation to four concentrations of cumulative exposure to cadmium (<400,400-999,1000-1999,>2000 mg. m 3. days).
After adjustment for age attained, year of hire, and Hispanic ethnicity, there was a significant positive trend (P<0.05) between cumulative exposure to cadmium and risks of mortality from lung cancer.
Relative to a risk of unity for the lowest exposure category (first level), risks were 2.30 (95% confidence interval (95% CI) 0.72 to 7.36), 2.83 (95% CI 0.75 to 10.72), and 3.88 (95% CI 1.04 to 14.46) for the second, third, and fourth categories, respectively. (...)
Mots-clés Pascal : Homme, Mortalité, Epidémiologie, Tumeur maligne, Bronchopulmonaire, Cadmium, Métal lourd, Toxicité, Carcinogène, Etude cohorte, Exposition professionnelle, Médecine travail, Poste travail, Etats Unis, Amérique du Nord, Amérique, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie, Histoire professionnelle
Mots-clés Pascal anglais : Human, Mortality, Epidemiology, Malignant tumor, Bronchopulmonary, Cadmium, Heavy metal, Toxicity, Carcinogen, Cohort study, Occupational exposure, Occupational medicine, Workplace layout, United States, North America, America, Respiratory disease, Lung disease, Bronchus disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0209245
Code Inist : 002B11A. Création : 21/05/1997.