Objectives-To investigate the risk of leukaemia in workers in the petroleum distribution industry who were exposed to low levels of benzene.
Methods-From the cohort of distribution workers, 91 cases were identified as having leukaemia on either a death certificate or on cancer registration.
These cases were compared with controls (four per case) randomly selected from the cohort, who were from the same company as the respective case, matched for age, and alive and under follow up at the time of case occurrence.
Work histories were collected for the cases and controls, together with information about the terminals at which they had worked, fuel compositions, and occupational hygiene measurements of benzene.
These data were used to derive quantitative estimates of personal exposure to benzene.
Odds ratios (OR) were calculated conditional on the matching, to identify those variables in the study which were associated with risk of leukaemia.
Examination of the potential effects of confounding and other variables was carried out with conditional logistic regression.
Analyses were carried out for all leukaemia and separately for acute lymphoblastic, chronic lymphocytic, acute myeloid and monocytic, and chronic myeloid leukaemias.
There was no significant increase in the overall risk of all leukaemias with higher cumulative exposure to benzene or with intensity of exposure, but risk was consistently doubled in subjects employed in the industry for>10 years. (...)
Mots-clés Pascal : Benzène, Essence, Commercialisation, Station service, Exposition professionnelle, Leucémie, Homme, Médecine travail, Etude cas témoin, Epidémiologie, Royaume Uni, Europe, Toxicité, Hémopathie maligne
Mots-clés Pascal anglais : Benzene, Gasoline, Marketing, Service station, Occupational exposure, Leukemia, Human, Occupational medicine, Case control study, Epidemiology, United Kingdom, Europe, Toxicity, Malignant hemopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0209240
Code Inist : 002B19B. Création : 21/05/1997.