The authors examined the effect of 24-hour nicotine patches in smoking cessation among over-the-counter customers in Denmark, based on a randomized double-blind placebo-controlled trial.
Participants were consecutive customers to whom nicotine patches were offered as the only treatment.
Forty-two pharmacies in the areas of Aarhus and Copenhagen in Denmark participated in the trial, and 522 customers who smoked 10 or more cigarettes per day were randomized to either nicotine patches or placebo from January to March 1994.
Customers with chronic diseases and pregnant or breastfeeding women were excluded from the trial.
Twenty-four-hour patches were offered free of charge during a 3-month period.
Those smoking 20 or more cigarettes per day started on a dose of 21-mg/day patches.
Customers who smoked less started on patches of 14 mg/day ; and for all of the participants, the dose was gradually reduced to 7-mg/day patches during the study period.
Smoking behavior and compliance were recorded by means of self-administered questionnaires and telephone interviews.
Smoking status was recorded in intervals of 4 weeks, which was fixed to be a treatment period, and 26 weeks after inclusion.
There was a significant increase in smoking cessation rates after 8 weeks of follow-up but only among smokers who started on 21-mg/day patches.
There was a marked placebo effect at each time of contact during the trial, especially in those smoking fewer than 20 cigarettes per day. (...)
Mots-clés Pascal : Tabagisme, Sevrage toxique, Tabac, Nicotine, Patch, Résultat, Traitement substitutif, Homme, Danemark, Europe, Randomisation, Etude en condition contrôlée
Mots-clés Pascal anglais : Tobacco smoking, Poison withdrawal, Tobacco, Nicotine, Patch, Result, Replacement therapy, Human, Denmark, Europe, Randomization, Controlled environment study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0205707
Code Inist : 002B18I15. Création : 21/05/1997.