In this article, biomedical literature assessing risks of nasal cancer and nonmalignant nasal pathology among woodworkers in North America is reviewed in detail and contrasted with experience from Europe and elsewhere.
Exceptionally high rates of nasa adenocarci-noma have occurred among European hardwood furniture workers, but the epidemiologic evidence documents a disparity in findings between North America and Europe.
Cohort studies of American wood-dust-exposed groups do not reveal excesses of nasal cancer, and wood-dust associations from US and Canadian case-control studies of nasal cancer tend not to be strong and differ accross studies.
Quantitative wood-dust exposure data are generally unavailable, but general dose information in European studies suggests that the excess risk of nasal cancer is associated with high levels of exposure.
There is also an inconsistent association between wood-dust exposure per se and mucostasis or nasal histologic changes, and the mucostasis/metaplasia/dysplasia route to nasal cancer is still an unverified hypothesis.
Considering the totality of evidence on the risk of cancer in exposed workers, it appears that wood-dust-related nasal adenocarcinoma essentially can be eliminated in Europe and its occurrence prevented in the United States if wood-dust exposures do not exceed an 8-hour time-weighted average 5 mg/m3 standard.
Mots-clés Pascal : Exposition professionnelle, Médecine travail, Homme, Tumeur maligne, Nez, Poussière, Bois, Carcinogène, Epidémiologie, Europe, Amérique du Nord, Amérique, Prévention, Relation dose réponse, Toxicité, ORL pathologie, Nez pathologie
Mots-clés Pascal anglais : Occupational exposure, Occupational medicine, Human, Malignant tumor, Nose, Dust, Wood, Carcinogen, Epidemiology, Europe, North America, America, Prevention, Dose activity relation, Toxicity, ENT disease, Nose disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0205516
Code Inist : 002B10B01. Création : 21/05/1997.