The authors ascertained cardiovascular events (myocardial infarction and angina pectoris) in 498 women with systemic lupus erythematosus seen at the University of Pittsburgh Medical Center from 1980 to 1993 (3,522 person-years).
Subjects were stratified by age, and cardiovascular event incidence rates were determined.
The authors compared these rates with cardiovascular event rates occurring over the same time period in 2,208 women of similar age participating in the Framingham Offspring Study (17,519 person-years).
Age-specific rate ratios were computed to determine whether the cardiovascular events in the lupus cohort were greater than expected.
The risk factors associated with cardiovascular events in women with lupus were determined.
There were 33 first events (11 myocardial infarction, 10 angina pectoris, and 12 both angina pectoris and myocardial infarction) after the diagnosis of lupus ; two thirds were under the age of 55 years at the time of event.
Women with lupus in the 35-to 44-year age group were over 50 times more likely to have a myocardial infarction than were women of similar age in the Framingham Offspring Study (rate ratio=52.43,95% confidence interval 21.6-98.5).
Older age at lupus diagnosis, longer lupus disease duration, longer duration of corticosteroid use, hypercholesterolemia, and postmenopausal status were more common in the women with lupus who had a cardiovascular event than in those who did not have an event. (...)
Mots-clés Pascal : Lupus érythémateux, Infarctus, Myocarde, Cardiopathie coronaire, Epidémiologie, Incidence, Age, Femme, Homme, Etats Unis, Amérique du Nord, Amérique, Etude comparative, Peau pathologie, Tissu conjonctif pathologie, Maladie système, Maladie autoimmune, Immunopathologie, Appareil circulatoire pathologie, Myocarde pathologie
Mots-clés Pascal anglais : Lupus erythematosus, Infarct, Myocardium, Coronary heart disease, Epidemiology, Incidence, Age, Woman, Human, United States, North America, America, Comparative study, Skin disease, Connective tissue disease, Systemic disease, Autoimmune disease, Immunopathology, Cardiovascular disease, Myocardial disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0205256
Code Inist : 002B07. Création : 21/05/1997.