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  1. Hepatitis E virus infection in haemodialysis patients : a seroepidemiological survey.

    Article - En anglais

    Background

    Hepatitis E virus (HEV) is the causative agent for enteric non-A, non-B hepatitis.

    Transmission is via the faecal route but the possibility of transmission by blood has been raised.

    Data concerning anti-HEV prevalence among chronic haemodialysis (HD) patients are few and give conflicting results.

    Methods

    We tested for anti-HEV antibody 204 chronic HD patients attending a single dialysis unit.

    A specific solid-phase enzyme-linked immunoassay (Abbott HEV EIA) was used.

    Results

    We found six anti-HEV-positive patients, the anti-HEV prevalence was 3% (95% CI 0-6%). The prevalence rates of HBV and HCV infections were 39% (31-45%) and 22% (16-28%) respectively.

    No anti-HEV-positive patient showed past or current biochemical signs of liver damage.

    One of six (17%) anti-HEV-positive patients was an immigrant ; no risk factor for anti-HEV antibody was identified in the other anti-HEV-positive individuals.

    Conclusions

    We observed a low anti-HEV prevalence ; there was no association between HEV and bloodborne infections (HBV, HCV, and HIV) in our HD patients ; most anti-HEV-positive patients we found were probably related to a local infection by HEV.

    This is one of the first reports concerning seroepidemiology of HEV infection in a large cohort of chronic HD individuals.

    Mots-clés Pascal : Hémodialyse, Hépatite virale E, Virose, Infection, Prévalence, Anticorps, Technique SPRIA, Epidémiologie, Italie, Europe, Homme, Epuration extrarénale, Appareil digestif pathologie, Foie pathologie

    Mots-clés Pascal anglais : Hemodialysis, Viral hepatitis E, Viral disease, Infection, Prevalence, Antibody, Solid phase radioimmunoassay, Epidemiology, Italy, Europe, Human, Extrarenal dialysis, Digestive diseases, Hepatic disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0204502

    Code Inist : 002B27B03. Création : 21/05/1997.