To determine the best cutoff values of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in detecting viral hepatitis C infection among patients of continuous ambulatory peritoneal dialysis (CAPD).
90 (44 male and 46 female) CAPD patients and 526 adult controls (266 male, 260 female) were enrolled.
Serum AST and ALT were measured by an auto-analyser monthly.
Serum HBsAg was examined using a RIA method and anti-HCV by an second-generation EIA method.
The best cutoff values of AST and ALT for detecting viral hepatitis were obtained from the ROC (receiver-operating characteristic) curve.
The prevalence of anti-HCV (+) was significantly higher in CAPD patients (16.7%) than in normal controls (4.9%), while that of HBsAg (+) was similar in both groups.
CAPD patients had significantly lower levels of serum aminotransferases compared to normal controls.
Mean AST were 23.8 IU/l in normal control and 18.8 IU/I in the CAPD patients (P<0.001).
Mean ALT were 21.9 IU/I in normal controls and 15.3 IU/I in the CAPD patients (P<0.001).
CAPD patients with HCV infection had higher serum AST and ALT levels than those without.
However, HBV infection did not cause significant serum aminotransferase elevation in patients.
The conventional cutoff values of AST (40 IU/l) and ALT (40 IU/l) for detecting viral hepatitis yielded only a sensitivity of 27.3 and 18. (...)
Mots-clés Pascal : Dialyse péritonéale, Ambulatoire, Continu, Hépatite virale C, Virose, Infection, Diagnostic, Transferases, Enzyme, Alanine, Aspartate, Activité enzymatique, Valeur, Taiwan, Asie, Homme, Epuration extrarénale, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Peritoneal dialysis, Ambulatory, Continuous, Viral hepatitis C, Viral disease, Infection, Diagnosis, Transferases, Enzyme, Alanine, Aspartate, Enzymatic activity, Value, Taiwan, Asia, Human, Extrarenal dialysis, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0204194
Code Inist : 002B27B03. Création : 21/05/1997.