In an annual survey for liver function tests in persons aged>35 years in Iwate Prefecture, Japan, a town was identified where high levels of alanine aminotransferase abounded.
Of 5152 inhabitants aged>35 years in this town, antibodies to hepatitis C virus (HCV) determined by enzyme-linked immunosorbent assay with HCV core peptides were detected in 798 (15.5%) people, hepatitis B surface antigen was detected in 47 (0.9%) people and antibodies to hepatitis B surface antigen and/or hepatitis B core antigen unaccompanied by surface antigenaemia were detected in 1748 (33.9%) people.
Antibodies to HCV core peptides correlated closely with the antibodies detected by passive haemagglutination with recombinant HCV proteins of the second generation.
Antibodies to HCV core peptides were particularly common in one of the nine districts of the town (district 8), where 276 (45.3%) of 609 inhabitants tested positive ; there were no differences in the frequency of serological markers of hepatitis B virus (HBV) infection among residents in the nine districts.
Of the 798 individuals with antibodies to HCV core peptides, 257 (32.2%) were found to have elevated transaminase levels.
A history of transfusion was associated with a high frequency of antibodies to HCV core peptides, except in district 8 where such antibodies were equally frequent in residents irrespective of transfusions. (...)
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Endémie, Mesure, Incidence, Séropositivité, Anticorps, Virus hépatite C, Flaviviridae, Virus, Taux concentration, Transaminases, Transferases, Enzyme, Protéine interne, Epidémiologie, Homme, Japon, Asie, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Endemy, Measurement, Incidence, Seropositivity, Antibody, Hepatitis C virus, Flaviviridae, Virus, Concentration factor, Transaminases, Transferases, Enzyme, Internal protein, Epidemiology, Human, Japan, Asia, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0195882
Code Inist : 002B05C02G. Création : 21/05/1997.