Clustering of childhood leukaemia in Hong kong : association with the childhood peak and common acute lymphoblastic leukaemia and with population mixing.
Incidence data of childhood leukaemia (CL) in Hong Kong (1984-90) have been analysed for evidence of variation between small areas.
All cases (n=261) were classified by morphological cell type, with the majority (n=205) being acute lymphoblastic leukaemia (ALL), and haematological review has permitted immunophenotypic classification for 73% of these.
The data have been examined for evidence of spatial clustering within small census areas (TPUs) and for association with population mixing, with attention focused on those subgroups (especially the childhood peak of ALL - taken here to be diagnoses in children from 24 months up to the seventh birthday - and common ALL) which, it has been hypothesized, may be caused by unusual patterns of exposure and response to common infections.
For the whole of Hong Kong, there was evidence of spatial clustering of ALL at ages 0-4 years (P=0.09) and in the childhood peak (P<0.05).
When these analyses were restricted to TPUs where extreme population mixing may have occurred, overall incidence was elevated and significant evidence of clustering was found for ALL (P<0.007) at these ages and for the common ALL in the childhood peak (P 0.032).
Replication of the analyses for subsets of leukaemia that were not dominated by the childhood peak of ALL found no evidence of clustering. (...)
Mots-clés Pascal : Leucémie lymphoblastique, Leucémie, Phénotype, Epidémiologie, Incidence, Répartition géographique, Analyse amas, Méthode statistique, Migration population, Hong Kong, Asie, Nourrisson, Homme, Enfant, Mongoloïde, Aigu, Hémopathie maligne, Lymphoprolifératif syndrome
Mots-clés Pascal anglais : Acute lymphocytic leukemia, Leukemia, Phenotype, Epidemiology, Incidence, Geographic distribution, Cluster analysis, Statistical method, Population migration, Hong Kong, Asia, Infant, Human, Child, Mongoloid, Acute, Malignant hemopathy, Lymphoproliferative syndrome
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0195386
Code Inist : 002B19B. Création : 21/05/1997.