Polymorphism in transporter antigen peptides gene (TAP1) associated with atopy in Tunisians.
Transporter antigen peptide 1 (TAP1) and TAP2 gene products from a transporter molecule involved in antigen presentation.
Polymorphic residues have been described in both genes and could have functional consequences in the immune response.
We designed a case-control study to investigate the potential association of polymorphism of the TAP1 gene with atopy.
We used the amplification refractory mutation system polymerase chain reaction to characterize TAP1 gene polymorphism in 84 unrelated Tunisian patients with atopy and 81 healthy control subjects.
Analysis of TAP1 polymorphism in Tunisian patients with atopy and in unaffected control subjects demonstrates a high relative risk (RR) of atopy in carriers of a codon (d) corresponding to a glycine at position 637 of the TAP1-B and TAP1-D alleles.
The relative risk of allergic asthma is markedly higher in homozygotes (d/d) (RR=22 ; p ¾ 0.0001).
The TAP1-D allele, not observed in European populations, has a frequency of 5% in the Tunisian control subject group.
A major increase of the frequency (f) of the D allele is observed in patients with allergic asthma (f=35%) and in those with allergic rhinitis (f=22%), indicating a high relative risk of allergic asthma (RR=10.2 p ¾0.0001) and of allergic rhinitis (RR=5.4 ; p ¾ 0.005) in individuals carrying this allele.
DD homozygotes were found only among patients with allergic asthma (23% of patients with astma). (...)
Mots-clés Pascal : Atopie, Asthme, Allergie, Gène, Variabilité génétique, Facteur risque, Epidémiologie, Etude cas témoin, Tunisie, Afrique, Homme, Immunopathologie, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Antigène TAP1
Mots-clés Pascal anglais : Atopy, Asthma, Allergy, Gene, Genetic variability, Risk factor, Epidemiology, Case control study, Tunisia, Africa, Human, Immunopathology, Respiratory disease, Obstructive pulmonary disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0193898
Code Inist : 002B06C02. Création : 21/05/1997.