Despite the considerable efforts and funds devoted to cancer research over several decades, cancer still remains a mainly lethal disease.
Cancer incidence and mortality have not declined at the same rate as other major causes of death, indicating that primary prevention remains a most valuable approach to decrease mortality.
There is general agreement that environmental exposures are variously involved in the causation of the majority of cancer cases and that at least half of all cancers could be avoided by applying existing etiologic knowledge.
There is disagreement, however, regarding the proportion of cancer risks attributable to specific etiological factors, including diet, occupation and pollution.
Estimates of attributable risks are largely based today on unverified assumptions and the calculation of attributable risks involves taking very unequal evidence of various types of factors and treating them equally.
Effective primary prevention resulting in a reduction of cancer risk can be obtained by : (i) a reduction in the number of carcinogens to which humans are exposed ; or (ii) a reduction of the exposure levels to carcinogens.
Exposure levels that could be seen as sufficiently low when based on single agents, may actually not be safe in the context of the many other concomitant carcinogenic and mutagenic exposures. (...)
Mots-clés Pascal : Mortalité, Tumeur maligne, Prévention, Facteur risque, Carcinogène, Exposition, Identification, Epidémiologie, Homme, Toxicité, Article synthèse
Mots-clés Pascal anglais : Mortality, Malignant tumor, Prevention, Risk factor, Carcinogen, Exposure, Identification, Epidemiology, Human, Toxicity, Review
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0193839
Code Inist : 002B04B. Création : 21/05/1997.