To understand the prognosis of newly diagnosed epilepsy to provide rational therapy and advice for patients and their physicians.
The National General Practice Study of Epilepsy (NGPSE) is the first large population-based study that has assessed the prognosis of patients with newly diagnosed epilepsy prospectively over a prolonged period.
We review the previously published data on the prognosis of epilepsy after 9 years of follow-up.
One thousand ninety-one patients with newly diagnosed or suspected epilepsy who were attending 1 of 275 general practices throughout the United Kingdom between 1984 and 1987 were ascertained.
Cases in this study were defined as the occurrence of one or more seizures, including provoked seizures.
Prognosis in terms of remission of seizures, and mortality, was analyzed in the patients who were classified 6 months after recruitment as having definite epilepsy (n=564) or possible/probable epilepsy (n=228).
Only 33 patients were completely lost to follow-up.
After 9 years, 86% [95% confidence interval (CI) 81,90] of patients with definite epilepsy had achieved a remission of 3 years, and 68% (CI 61,75), had achieved a remission of 5 years.
For the complete cohort, with possible/probable epilepsy included, the rates increased to 87% (CI 83,91) for 3-year remission and 71% (CI 65,77) for 5-year remission. (...)
Mots-clés Pascal : Epilepsie, Idiopathique, Rémission, Mortalité, Etiologie, Angleterre, Grande Bretagne, Royaume Uni, Europe, Pronostic, Evolution, Etude cohorte, Epidémiologie, Homme, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie
Mots-clés Pascal anglais : Epilepsy, Idiopathic, Remission, Mortality, Etiology, England, Great Britain, United Kingdom, Europe, Prognosis, Evolution, Cohort study, Epidemiology, Human, Nervous system diseases, Central nervous system disease, Cerebral disorder
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0188301
Code Inist : 002B17A03. Création : 21/05/1997.