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  1. The clinical efficacy of trivalent oral polio vaccine in the Gambia by season of vaccine administration.

    Article - En anglais

    An epidemic of poliomyelitis caused by poliovirus type 1 occurred in The Gambia in 1986.

    To determine if a relationship existed between the failure of trivalent oral poliovirus vaccine (OPV) to prevent poliomyelitis and the season when children were vaccinated, 46 children 1-7 years old with poliomyelitis who had received three card-documented doses of OPV were compared with 260 controls who had also received three card-documented doses.

    Controls were individually matched with children who had poliomyelitis by age, sex, and residence.

    Children with poliomyelitis were more likely to have received doses in the rainy season (odds ratio describing the linear trend of each additional dose in the rainy season, 1.7 ; 95% confidence interval, 1.05-2.9).

    This finding extends previous observations of seasonal difference in the immunogenicity of OPV in The Gambia by showing that season of administration was associated with increased risk of vaccine failure nationwide for a several-year period.

    Mots-clés Pascal : Poliomyélite antérieure, Virose, Infection, Poliovirus, Enterovirus, Picornaviridae, Virus, Immunoprophylaxie, Vaccination, Vaccin polyvalent, Evaluation, Efficacité, Relation, Saison, Morbidité, Etude cas, Enfant, Homme, Gambie, Afrique, Système nerveux pathologie, Système nerveux central pathologie, Moelle épinière pathologie

    Mots-clés Pascal anglais : Acute anterior poliomyelitis, Viral disease, Infection, Poliovirus, Enterovirus, Picornaviridae, Virus, Immunoprophylaxis, Vaccination, Polyvalent vaccine, Evaluation, Efficiency, Relation, Season, Morbidity, Case study, Child, Human, Gambia, Africa, Nervous system diseases, Central nervous system disease, Spinal cord disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0188145

    Code Inist : 002B05A02. Création : 21/05/1997.