Sequential use of inactivated poliovirus vaccine followed by oral poliovirus vaccine in Oman.
Seroprevalence and geometric mean titers (GMTs) were compared at 6 and 10 months after vaccination with monovalent type 1 oral poliovirus vaccine (OPV) at 6 months and trivalent OPV at 7 and 9 months.
Group I had received 4 doses of OPV, group 2 OPV at birth and 3 doses of OPV and inactivated poliovirus vaccine (IPV), and group 3 placebo at birth and 3 doses of IPV.
A total of 547 infants completed the study.
At 10 months, seroprevalence to poliovirus type 1 was 98%, 99%, and 98% in groups 1,2, and 3 ; 100%, 100%, and 98% to poliovirus type 2 ; and 80%, 96%, and 91% to poliovirus type 3. Differences in seroprevalence among the groups were significant for poliovirus type 3 (P<. 001).
Between 6 and 10 months, significant increases in seroprevalence and GMTs occurred for poliovirus type 1 but not for types 2 and 3. Two OPV doses following 3 IPV doses did not significantly increase seroprevalence or raise GMTs for poliovirus types 2 and 3 ; however, significant increases were found for poliovirus type 1, which may have benefitted from monovalent type 1 administration.
Mots-clés Pascal : Poliomyélite antérieure, Virose, Infection, Immunoprophylaxie, Vaccination, Séquentiel, Poliovirus, Enterovirus, Picornaviridae, Virus, Voie orale, Inactivation, Mesure, Séropositivité, Vaccin polyvalent, Evolution, Etude comparative, Enfant, Homme, Oman, Asie, Système nerveux pathologie, Système nerveux central pathologie, Moelle épinière pathologie
Mots-clés Pascal anglais : Acute anterior poliomyelitis, Viral disease, Infection, Immunoprophylaxis, Vaccination, Sequential, Poliovirus, Enterovirus, Picornaviridae, Virus, Oral administration, Inactivation, Measurement, Seropositivity, Polyvalent vaccine, Evolution, Comparative study, Child, Human, Oman, Asia, Nervous system diseases, Central nervous system disease, Spinal cord disease
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0188142
Code Inist : 002B05A02. Création : 21/05/1997.