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  1. Combined immunization of infants with oral and inactivated poliovirus vaccines : Results of a randomized trial in The Gambia, Oman, and Thailand.

    Article - En anglais

    To assess an immunization schedule combining oral (OPV) and inactivated poliovirus vaccines (IPV), a clinical trial was conducted in The Gambia, Oman, and Thailand.

    Children were randomized to receive OPV at birth and at 6,10, and 14 weeks of age ; OPV at birth followed by both OPV and IPV at 6,10, and 14 weeks of age ; or placebo at birth followed by IPV at 6,10, and 14 weeks of age.

    Serum specimens were available at 24 weeks for 1291 (77%) of 1685 enrolled infants.

    In the combined-schedule group, the proportion of children seropositive at 24 weeks was 95% - 99% for type 1,99% - 100% for type 2, and 97% - 100% for type 3. In The Gambia and Oman, the combined schedule performed significantly better than OPV for type 1 (95% - 97% vs. 88% - 90%) and type 3 (97% - 99% vs. 72% - 73%). Across the study sites, IPV given at 6,10, and 14 weeks of age provided inadequate protection against poliovirus.

    The combined schedule provided the highest levels of serum antibody response, with mucosal immunity equivalent to that produced by OPV alone.

    Mots-clés Pascal : Poliomyélite antérieure, Virose, Infection, Poliovirus, Enterovirus, Picornaviridae, Virus, Stratégie, Eradication, Immunoprophylaxie, Vaccination, Voie orale, Association, Inactivité biologique, Résultat, Enfant, Homme, Système nerveux pathologie, Système nerveux central pathologie, Moelle épinière pathologie

    Mots-clés Pascal anglais : Acute anterior poliomyelitis, Viral disease, Infection, Poliovirus, Enterovirus, Picornaviridae, Virus, Strategy, Eradication, Immunoprophylaxis, Vaccination, Oral administration, Association, Biological inactivity, Result, Child, Human, Nervous system diseases, Central nervous system disease, Spinal cord disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0188140

    Code Inist : 002B05A02. Création : 21/05/1997.